Pesquisa | SciELO

Abstract Background Hereditary or familial spastic paraplegias (SPG) comprise a group of genetically and phenotypically heterogeneous diseases characterized by progressive degeneration of the corticospinal tracts. The complicated forms evolve with other various neurological signs and symptoms, including movement disorders and ataxia. Objective To summarize the clinical descriptions of SPG that manifest with movement disorders or ataxias to assist the clinician in the task of diagnosing these diseases. Methods We conducted a narrative review of the literature, including case reports, case series, review articles and observational studies published in English until December 2022. Results Juvenile or early-onset parkinsonism with variable levodopa-responsiveness have been reported, mainly in SPG7 and SPG11. Dystonia can be observed in patients with SPG7, SPG11, SPG22, SPG26, SPG35, SPG48, SPG49, SPG58, SPG64 and SPG76. Tremor is not a frequent finding in patients with SPG, but it is described in different types of SPG, including SPG7, SPG9, SPG11, SPG15, and SPG76. Myoclonus is rarely described in SPG, affecting patients with SPG4, SPG7, SPG35, SPG48, and SPOAN (spastic paraplegia, optic atrophy, and neuropathy). SPG4, SPG6, SPG10, SPG27, SPG30 and SPG31 may rarely present with ataxia with cerebellar atrophy. And autosomal recessive SPG such as SPG7 and SPG11 can also present with ataxia. Conclusion Patients with SPG may present with different forms of movement disorders such as parkinsonism, dystonia, tremor, myoclonus and ataxia. The specific movement disorder in the clinical manifestation of a patient with SPG may be a clinical clue for the diagnosis.

Resumo Antecedentes As paraplegias espásticas hereditárias ou familiares (SPG) compreendem um grupo de doenças geneticamente e fenotipicamente heterogêneas caracterizadas por degeneração progressiva dos tratos corticospinais. As formas complicadas evoluem com vários outros sinais e sintomas neurológicos, incluindo distúrbios do movimento e ataxia. Objetivo Resumir as descrições clínicas de SPG que se manifestam com distúrbios do movimento ou ataxias para auxiliar o clínico na tarefa de diagnosticar essas doenças. Métodos Realizamos uma revisão da literatura, incluindo relatos de casos, séries de casos, artigos de revisão e estudos observacionais publicados em inglês até dezembro de 2022. Resultados O parkinsonismo juvenil ou de início precoce com resposta variável à levodopa foi relatado principalmente em SPG7 e SPG11. A distonia pode ser observada em pacientes com SPG7, SPG11, SPG22, SPG26, SPG35, SPG48, SPG49, SPG58, SPG64 e SPG76. O tremor não é um achado frequente em pacientes com SPG, mas é descrito em diferentes tipos de SPG, incluindo SPG7, SPG9, SPG11, SPG15 e SPG76. A mioclonia é raramente descrita em SPG, afetando pacientes com SPG4, SPG7, SPG35, SPG48 e SPOAN (paraplegia espástica, atrofia óptica e neuropatia). SPG4, SPG6, SPG10, SPG27, SPG30 e SPG31 podem raramente apresentar ataxia com atrofia cerebelar. E SPG autossômico recessivo, como SPG7 e SPG11, também pode apresentar ataxia. Conclusão Indivíduos com SPG podem apresentar diferentes formas de distúrbios do movimento, como parkinsonismo, distonia, tremor, mioclonia e ataxia. O distúrbio específico do movimento na manifestação clínica de um paciente com SPG pode ser uma pista clínica para o diagnóstico.

https://doi.org/10.1055/s-0043-1777005

Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer
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Tobias-Machado, Marcos

; Ornellas, Antonio A.

; Hidaka, Alexandre K.

; Medina, Luis G.

; Mattos, Pablo A. L.

; Besio, Ruben S.

; Abreu, Diego

; Castro, Pedro R.

; Nishimoto, Ricardo H.

; Astigueta, Juan

; Dourado, Aurus

; Machado, Roberto D.

; Magnabosco, Wesley J.

; Corona-Montes, Victor

; Villoldo, Gustavo M.

; Zampolli, Hamilton C.

; Taha, Anis

; Auad, Pericles R.

; Faria, Eliney F.

; Arantes, Paulo B. O.

; Tavares, Alessandro

; Nascimento, Francisco S. M. S.

; Brazão Jr., Eder S.

; Rocha, Maurício M.

; Costa, Walter H.

; Panico, Vinicius

; Reis, Leonardo O.

; Almeida-Carrera, Roberto J.

; Silva, Rafael C.

; Zequi, Stênio C.

; Calixto, José R. R.

; Sotelo, Rene

International braz j urol

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Out 2023, Volume 49 Nº 5 Páginas 580 - 589

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

https://doi.org/10.1590/s1677-5538.ibju.2023.0065

Characterization of Flavonoids Profiles in Polar Extracts from Croton grewioides Baill. Using Ultra-High Resolution Mass Spectrometry Baill UltraHigh Ultra High
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Nascimento, Pedro E. S. do

; Prado, Vilma M. J.

; Jesus, Raphael A. de

; Silva, Wenes R. da

; Wisniewski Jr., Alberto

; Sá Filho, José C. F.

; Blank, Arie F.

; Souza, Daniel A. de

; Wartha, Elma R. S. A.

; Nogueira, Paulo C. L.

; Moraes, Valéria R. S.

Journal of the Brazilian Chemical Society

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Jul 2023, Volume 34 Nº 7 Páginas 937 - 948

Resumo: En | Texto: En | PDF: En

Research to identify plant bioactive compounds led to the evolution of extraction methods. This study optimized ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) to extract the flavonoids of Croton grewioides Baill. species contributing to characterize the polar extract profile and understand the antioxidant potential of these plant constituents. The use of experimental design and statistical treatments enabled the determination of the ideal conditions for each technique. The extracts of five accessions of C. grewioides were obtained under the optimized extraction conditions and were analyzed using ultra high-resolution mass spectrometry (FT-Orbitrap MS) operating at negative ionization mode for flavonoids detection. The accurate experimental mass obtained to the main compounds was used to attribute the molecular formula. Chemical structures of the main compounds detected were proposed using structure data bases. Chemometric analysis were performed with two FT-Orbitrap MS spectra samples using the identified metabolites and, the antioxidant activity data, showing that for this species the MAE was most effective in extracting the antioxidant compounds. It was possible to propose the structures for forty compounds in the C. grewioides extracts, demonstrating the excellent performance of the FT-Orbitrap MS in providing information on the chemical profile of polar compounds in plant extracts. methods ultrasoundassisted ultrasound assisted UAE (UAE microwaveassisted microwave (MAE Baill constituents technique C highresolution high resolution FTOrbitrap FT Orbitrap detection formula bases

https://doi.org/10.21577/0103-5053.20230004

Guía de práctica clínica para el manejo del cáncer de pulmón de células pequeñas: enfermedad extensa
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Cabrera-Miranda, Luis A.

; Díaz-García, Diego A.

; Corona-Cruz, José F.

; Lozano-Ruiz, Francisco J.

; Sánchez-Reyes, Roberto

; Álvarez-Bojórquez, Mario E.

; Blake-Cerda, Mónika

; Rivera-Márquez, Raúl

; López-Saucedo, Raúl A.

; Pérez-Álvarez, Sandra I.

; Bolaño-Guerra, Laura M.

; Alatorre-Alexander, Jorge A.

; Alexander-Meza, Francisco

; Barrón-Barrón, Feliciano

; Blanco-Vázquez, Yazmín C.

; Campos-Gómez, Saúl

; Mata-Moya, Dolores de la

; Figueroa-Martínez, Pedro

; González-Cisneros, Paulina E.

; Íñiguez-García, Marco A.

; Lázaro-León, Jesús M.

; Loyola-García, Ulises

; Morales-Rivera, Marcelino

; Olivares-Torres, Carlos

; Ramos-Ramírez, Maritza

; Sáenz-Frías, Julia A.

; Silva-Bravo, Fernando

; Trejo-Rosales, Rogelio

; Souto-del Bosque, Miguel

; Arrieta, Óscar

Gaceta mexicana de oncología

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Jun 2023, Volume 22 Nº 2 Páginas 55 - 73

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP enfermedad extensa en México basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración del Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad extensa, producto de preguntas de trabajo. Se identificó y evaluó la evidencia científica que responde a cada una de dichas preguntas clínicas antes de incorporarla al cuerpo de la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad extensa del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica para estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by its rapid growth rate and the rapid development of distant metastases. Objectives: To guide and standardize the treatment of extensive disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: A consensus was reached, both by the Delphi method and in remote meetings, of extensive disease recommendations resulting from work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the Guide. Conclusions: This Clinical Practice Guide provides clinical recommendations for the management of extensive disease of SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

https://doi.org/10.24875/j.gamo.22000122

Prototipo de exploración educativa basada en realidad mixta para cirugía con casco Meta 2
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Aguilar, Eliana

; Solarte Correa, Pedro L.

; Dorado, Jesús H.

; Sabater, José María

; Vivas Albán, Oscar A.

Ingeniería

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Abr 2023, Volume 28 Nº 1 elocation e18543

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Contexto: Los cirujanos de intervenciones mínimamente invasivas requieren ampliar la información para realizar las rutas de intervención, este artículo describe un prototipo de realidad mixta de carácter educativo o pre quirúrgico que hace uso del Casco Metavision Meta II. Se crearon objetos 3D de estructuras morfológicas para neurocirugía y laparoscopia a partir de imágenes obtenidas de resonancia magnética MRI y TAC de un paciente real, con el fin de simular el acceso al cerebro y hacer reconocimiento del área abdominal. Métodos: Este prototipo tiene un enfoque educativo cuyo objetivo es incentivar el reconocimiento de esquemas morfológicos de órganos, para lo cual se diseñaron tres pruebas. Estas pruebas consistieron en la búsqueda de tumores a través de la navegación y la interacción con un objeto exhibido en el casco de realidad mixta Meta 2. Para el área neurológica se dedicaron dos de las tres pruebas, en las dos primeras pruebas se midió el tiempo de búsqueda con cinco tumores, y para el área abdominal se realizó también una prueba para la búsqueda de dos tumores, diseñándose diversas interacciones en el recorrido espacial del objeto 3D generado, usando pantallas con despliegues de los cortes tomados de imágenes de tomografía computarizada. Posterior al desarrollo de las tres pruebas se realizó un proceso de medición de inmersión a partir del uso de un cuestionario. Resultados: El 100% de los usuarios encontró altamente interesante la aplicación, en tanto que el 90% expresó que intentó fijar su foco de atención en el desarrollo exitoso de la prueba, indicador del nivel de absorción de la aplicación. También el 70% de los usuarios describió su experiencia como de alto nivel de inmersión. Conclusiones: Las pruebas demostraron que el prototipo es usable, absorbente y tiene un nivel de inmersión aceptable.

Abstract Context: This article describes an educational or pre-surgical mixed-reality prototype using the Metavision Meta II headset. 3D objects of morphological structures for neurosurgery and laparoscopy were created from MRI and CT images of a real patient in order to simulate the access to the brain and conduct a reconnaissance of the abdominal area. Method: This prototype has an educational approach whose objective is to encourage the recognition of morphological schemes of organs, for which three tests were designed. These tests consisted of searching for tumors through navigation and interaction with an object displayed in the Meta 2 mixed-reality headset. Two of the three tests were dedicated to the neurological area, in which the search time was measured with five tumors, and a test was conducted for the abdominal area regarding the search of two tumors, designing various interactions in the spatial path of the generated 3D object. An immersion measurement process was conducted which was based on the use of a questionnaire. Results: 100% of users found the application highly interesting, while 90% expressed that they tried to focus their attention on the successful completion of the test, an indicator of the level of absorption of the application. Furthermore, 70% of users described their experience as highly immersive. Conclusions: Tests showed the prototype to be usable, absorbent, and has an acceptable level of immersion.

https://doi.org/10.14483/23448393.18543

Mechanical behaviour of grapevine wood affected by Xylotrechus arvicola
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Rodríguez-González, Álvaro

; Casquero, Pedro A.

; Pereira, José A.

; González-López, Óscar

; Guerra, Marcos

; García-González, Julia

; Morán-Del Pozo, Julia M.

; Juan-Valdés, Andrés

Maderas. Ciencia y tecnología

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2023, Volume 25 elocation 16

Resumo: En | Texto: En | PDF: En

Abstract: The cerambycid insect Xylotrechus arvicola is considered a pest that affects the wood of the grapevine (Vitis vinifera) in the major wine areas of the Iberian Peninsula. The larva of this insect perforates the grapevine wood, resulting in structural and biomechanical failure of the vine plants. Vine samples from wood damaged by X. arvicola larvae were picked up from different vineyards and grape varieties. Compressive and flexural tests were performed in order to assess the mechanical behaviour of the wood samples. Total length of the cracks in wood samples (TLCWS) that appeared on the surface of the grapevine wood samples after the mechanical tests was measured. Compressive strength (CS) and flexural strength (FS) decreased with the increase of the cross-sectional area (CSA) of both branches and trunks, regardless of damage condition or water content. Moreover, the resistance was lower in damaged wood. In addition, this was verified through the linear regression coefficients of the interaction CS x CSA and FS x CSA. TLCWS in branches and trunks of damaged samples was greater that in undamaged samples. Also, TLCWS within the same damage condition and part of the plant was higher in dry samples than in fresh samples. The damaged wood would show a higher vulnerability to common mechanical stress suffered by the grapevines in the field including heavy winds, fruit overweight or harvesting machines shaking (when mechanically collected). Larvae of this insect altered the mechanical behaviour of the trunk and branches of grapevine wood. The mechanical strength of wood was more negatively affected when the CSA of the branches and trunks increased. Longer TLCWS was found in affected wood.

https://doi.org/10.4067/s0718-221x2023000100416

Hepatitis A seroprevalence among special populations in the Rio de Janeiro Metropolitan Area, Brazil
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Carvalho, Flavio de

; Brandão, Luciana Gomes Pedro

; Varela, Margaret Catoia

; Tuyama, Mari

; Correa, Danusa Ferreira

; Santos, Ananza Taina da Silva

; Lemos, Alberto dos Santos de

; Costa, Marcellus Dias da

; Cerbino-Neto, José

; Brasil, Pedro Emmanuel Alvarenga Americano do

Cadernos de Saúde Pública

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2023, Volume 39 Nº 2 elocation e00075522

Resumo: Pt Es En | Texto: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Este estudo teve como objetivo estimar a soroprevalência do vírus da hepatite A, em indivíduos atendidos em uma clínica de medicina de viagem e imunização no Rio de Janeiro, Brasil, e desenvolver um modelo de predição para a soroprevalência do vírus da hepatite A. Esta pesquisa retrospectiva incluiu indivíduos sequencialmente de abril de 2011 a junho de 2019, em uma clínica de medicina de viagem e uma clínica de vacinação de população especial, que, por qualquer motivo, tem um resultado de quimioluminescência IgG antivírus da hepatite A . Os dados dos participantes foram verificados em prontuário eletrônico. Os dados foram divididos em desenvolvimento e validação, tomando 2018 como data limite da divisão. Um modelo linear generalizado elástico com distribuição binomial submetido a validação cruzada foi aplicado. Foram analisados 2.944 indivíduos atendidos. A soroprevalência geral do vírus da hepatite A foi de 67,8%. Profissionais de saúde, viajantes e contatantes de indivíduos imunocomprometidos apresentaram menor soroprevalência, variando de 40% a 55%, enquanto indivíduos com condições crônicas (coração, pulmão e fígado) tiveram soroprevalência variando de 89% a 94%. Os preditores retidos no modelo final foram sexo, idade, ano de nascimento, viajantes, HIV/aids, asplenia funcional, candidatos a transplante, comunicante domiciliar, imunossupressão relacionada ao câncer e profissionais de saúde. A área sob a curva foi de 0,836 e o erro máximo foi de 0,051. Os usuários podem fazer previsões com uma calculadora (https://pedrobrasil.shinyapps.io/INDWELL/). Os grupos com menor soroprevalência devem ser avaliados com mais cuidado quanto à necessidade de vacinação contra o vírus da hepatite A, mesmo quando procuram clínicas de vacinação para outros fins.

Los objetivos del estudio son estimar la seroprevalencia de hepatitis A en sujetos que asisten a una clínica de medicina para viajeros e inmunización en Río de Janeiro, Brasil, y desarrollar un modelo de predicción de la seroprevalencia de hepatitis A. Esta investigación de seguimiento retrospectivo incluyó a individuos de forma secuencial desde abril de 2011 hasta junio de 2019 en una clínica de medicina para viajeros y de vacunación de poblaciones especiales que por cualquier motivo tienen un resultado de quimioluminiscencia IgG anti-hepatitis A. Los datos de los participantes se verificaron en los registros médicos electrónicos. Los datos se dividieron en conjunto de desarrollo y validación tomando 2018 como fecha de corte. Se realizó un modelo lineal generalizado validado cruzado elástico con distribución binomial. Se analizaron un total de 2.944 sujetos atendidos. La seroprevalencia global del hepatitis A fue del 67,8%. Los profesionales sanitarios, los viajeros y las personas en contacto con sujetos inmunodeprimidos presentaron una seroprevalencia más baja, que osciló entre el 40% y el 55%, mientras que los sujetos con afecciones crónicas (cardíacas, pulmonares y hepáticas) presentaron una seroprevalencia que varió entre el 89% y el 94%. Los predictores retenidos en el modelo final fueron el sexo, la edad, el año de nacimiento, los viajeros, el VIH/SIDA, la disfunción del bazo, los candidatos a trasplante, los comunicadores domésticos, la inmunosupresión relacionada con el cáncer y los profesionales sanitarios. Su área bajo la curva fue de 0,836 y el error máximo de 0,051. Los usuarios pueden hacer predicciones con una calculadora (https://pedrobrasil.shinyapps.io/INDWELL/). Los grupos con menor seroprevalencia deben ser evaluados más cuidadosamente en cuanto a la necesidad de vacunación contra hepatitis A, incluso cuando acudan a las clínicas de vacunación con otros fines.

The objectives were to estimate hepatitis A virus seroprevalence in subjects attending to a travel medicine and immunization clinic in Rio de Janeiro, Brazil, and to develop a prediction model for hepatitis A virus seroprevalence. This retrospective research included individuals sequentially from April 2011 to June 2019 at a travel medicine and special population immunization clinic with an anti-hepatitis A virus IgG chemiluminescence result. Participants’ data were verified via electronic medical records. Data were split into development and validation set taking 2018 as the date break. A cross-validated elastic generalized linear model with binomial distribution was performed. In total, 2,944 subjects were analyzed. Hepatitis A virus overall seroprevalence was 67.8%. Health professionals, travelers, and those who had contact with immunocompromised subjects had lower seroprevalence (40%-55%), whereas subjects with chronic conditions (heart, lung, and liver) ranged from 89% to 94%. The retained predictors in the final model were sex, age, year of birth, travelers, HIV/AIDS, spleen dysfunction, transplant candidates, household communicators, cancer-related immunosuppression, health care professionals. Area under the curve was 0.836 and maximum error was 0.051. Users can make predictions with the following calculator: https://pedrobrasil.shinyapps.io/INDWELL/. The groups with lower seroprevalence should be evaluated more carefully regarding need for hepatitis A virus vaccination even when they seek immunization clinics for other purposes.

https://doi.org/10.1590/0102-311xen075522

Lesiones vertebrales postraumáticas
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Bazán, Pedro L.

; Cortes Luengo, Carlos

; Borri, Álvaro E.

; Medina, Martín

; Ciccioli, Nicolás M.

; Poza Roman, Daiana D.

; Patalano, Luis

; Moreno, Pablo B.

; Casco, Enrique A.

; Marin, Elio

; Godoy Adaro, Alfredo O.

; Gutierrez, Edgar E.

; Avero Gonzalez, Richard A.

; Acevedo Yoga, Joel

; Soria Adaro, José C.

; Terraza, Sergio

; Belloni Barreto, Alex

Revista de la Asociación Argentina de Ortopedia y Traumatología

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2023, Volume 88 Nº 2 Páginas 138 - 147

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Introduction: Spinal injuries are common among young adult men. Recognizing kinematics can help reduce the number of late diagnoses, especially if there are consciousness disorders. Vertebral fractures can be single or multiple, and they are often associated with extravertebral injuries. Objectives: To examine the distribution of the lesion based on the mechanism of production, to characterize the neurological condition, to evaluate the lesion pattern and its relationship with extravertebral lesions, and to analyze the treatment. Materials and Methods: This was a multicenter, prospective study of patients admitted with post-trauma vertebral injuries between July 1, 2018 and June 30, 2020. Age, gender, kinematics, neurological condition, affected sector, pattern of injury, and associated extravertebral injuries were all examined. Results: There were 281 patients (60% men) evaluated, with 400 vertebral and 118 extravertebral lesions. The causes were as follows: polytrauma in 62 cases, falls from great heights in 147 patients, and traffic accidents in 98. ASIA E was the most frequently observed neurological picture (8 cases), which was not determined at admission. The T2-L5 sector was the most affected, mostly by compression injuries. Head and chest trauma were the most common extravertebral injuries; there was one case of SCIWORA and one early death. Conclusions: The most commonly affected spinal sectors were thoracolumbar, thoracic, and lumbar; the injuries are typically caused by falls from great heights and, in general, are isolated, with no neurological injuries. The treatment is determined by the stability and neurological condition.

Resumen Introducción: Las lesiones raquídeas son frecuentes en hombres adultos jóvenes. Reconocer la cinemática ayuda a disminuir la tasa de diagnósticos tardíos, principalmente si hay trastornos de la conciencia. Las fracturas vertebrales pueden ser únicas o múltiples, y asociarse con lesiones extravertebrales. Los objetivos de este estudio fueron analizar la distribución de la lesión según el mecanismo de producción, caracterizar el cuadro neurológico, evaluar el patrón de lesión y la asociación con lesiones extravertebrales, y analizar el tratamiento. Materiales y Métodos: Estudio multicéntrico, prospectivo de pacientes con lesiones vertebrales postrauma, que ingresaron entre el 1 de julio de 2018 y el 30 de junio de 2020. Se analizaron los siguientes parámetros: edad, sexo, cinemática, cuadro neurológico, sector afectado, patrón de lesión, lesiones extravertebrales asociadas. Resultados: Se evaluó a 281 pacientes (60% hombres) con 400 lesiones vertebrales y 118 extravertebrales que, en 62 casos, conformaban un cuadro de politraumatismo; 147 con trauma por caída de altura y 98, por accidente de tránsito. El cuadro neurológico más observado fue ASIA E (8 casos), no determinado al ingreso. El sector T2-L5 fue el más afectado, en su mayoría, por lesiones por compresión. Las lesiones extravertebrales más frecuentes fueron el trauma de cráneo y de tórax; hubo un caso de SCIWORA y un óbito temprano. Conclusiones: Los sectores raquídeos más afectados fueron: el toracolumbar, el torácico y el lumbar; las lesiones suelen deberse a caídas de altura y suelen ser únicas, sin cuadro neurológico. El tratamiento se decide según la estabilidad y el cuadro neurológico.

https://doi.org/10.15417/issn.1852-7434.2023.88.2.1510

Hepatitis A seroprevalence among special populations in the Rio de Janeiro Metropolitan Area, Brazil
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Carvalho, Flavio de

; Brandão, Luciana Gomes Pedro

; Varela, Margaret Catoia

; Tuyama, Mari

; Correa, Danusa Ferreira

; Santos, Ananza Taina da Silva

; Lemos, Alberto dos Santos de

; Costa, Marcellus Dias da

; Cerbino-Neto, José

; Brasil, Pedro Emmanuel Alvarenga Americano do

Cadernos de Saúde Pública

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2023, Volume 39 Nº 2 elocation e00075522

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0102-311xen075522

10.

Deep sea ecosystem exploration and ‘health check’: sampling strategy and methods applied during the iAtlantic_BR10_Petrobras cruise in the Santos Basin, Southwest Atlantic
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Perez, Jose Angel A.

; Barros Neto, Halésio M.C. de

; Arantes, Renata C.M.

; Gaurisas, Daniela Y.

; Silva, Camila F.

; Alves, Fernanda Maria M.

; Costa, Júlia A.

; Eloi, Paula D.C.

; Fonseca, Thayse S.

; Gavazzoni, Lucas

; Lonskis, Isabella da S.

; Nardi, Ricardo U.

; Nascimento, Pedro O.

; Rodrigues, João Vitor M.

; Santos, Ana Lara F. dos

; Santos, Edson C. dos

; Schroeder, Rafael

; Silva, Luis Carlos da

; Souza, Fernanda dos S.S. de

; Bernardino, Ângelo F.

; Cavalcanti, Guarani H.

; Lindner, Alberto

; Mahiques, Michel M. de

; Millo, Christian

; Reis, Priscila

; Sweetman, Andrew K.

; Roberts, J. Murray

Ocean and Coastal Research

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2023, Volume 71 elocation e23046

Resumo: En | Texto: En | PDF: En

Abstract The iAtlantic Project has established an international collaborative strategy to improve mapping and characterization of deep and open ocean ecosystems in understudied regions of the Atlantic and evaluate their health. In December 2022, the first iAtlantic expedition in the South Atlantic set off to map and explore seafloor ecosystems in the Santos Basin slope (200-1,000 m depths) in collaboration with the Petrobras ‘Santos Basin - Regional Characterization Project.’ The 17-day ‘iAtlantic_BR10-Petrobras’ cruise was conducted on board the research vessel NPqHOc Vital de Oliveira (Brazilian Navy) and performed (a) water column structure characterization, (b) seafloor morphology mapping, (c) description of benthic habitats and communities by seafloor imagery and biological/ geological sampling, and (d) ex-situ experiments to assess the functioning of sedimentary ecosystems and their responses to climate-related environmental changes. This study describes the rationale behind the iAtlantic_BR10-Petrobras cruise science plan, reports its sampling strategy and methods, and summarizes its collected data and preliminary results.

https://doi.org/10.1590/2675-2824071.23069jaap

11.

Crecimiento, rendimiento y rentabilidad de calabacita (Cucurbita pepo L.) fertilizada con fuentes químicas y biológicas
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Aguilar-Carpio, Cid

; Cervantes-Adame, Yessica Flor

; Sorza-Aguilar, Pedro Jordan

; Escalante-Estrada, José Alberto Salvador

Terra Latinoamericana

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Dez 2022, Volume 40 elocation e1059

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen: La calabacita es una hortaliza de gran relevancia agrícola y social en México, por lo que la implementación de alternativas como el uso de productos de origen biológico, puede contribuir al mejoramiento y al incremento de las ganancias en este cultivo. El objetivo del estudio fue determinar el efecto de la fertilización química y biológica en el crecimiento, rendimiento y rentabilidad del cultivo de la calabacita. El estudio se estableció bajo riego en Tlayacapan, Morelos, México, donde se trasplantó plántulas de calabacita italiana variedad Adelita, los tratamientos consistieron en la aplicación al suelo de extracto de algas marinas [Ascophyllum nodosum (L.) Le Jolis] y Rhizophagus irregularis (Błaszk., Wubet, Renker & Buscot) C. Walker & A. Schüßler (2010) en mezcla con fertilizantes químicos. Se utilizó un diseño de bloques completos al azar con cuatro repeticiones. Para evaluar el crecimiento del cultivo, se registró el área foliar, materia seca por planta, con el cual se determinó la tasa de crecimiento del cultivo, tasa absoluta de crecimiento, rendimiento del cultivo, peso, diámetro y largo del fruto. También se realizó un análisis económico para determinar la rentabilidad de cada tratamiento. En general, se observó que la aplicación de la fertilización química al 100% promovió la mayor área foliar, peso fresco de la planta, materia seca, tasa absoluta de crecimiento, tasa de crecimiento del cultivo, rendimiento y peso de fruto en el cultivo de calabacita, lo que generó una mejor rentabilidad. La fertilización con algas marinas complementó la fertilización química y generó una mejor respuesta en las variables evaluadas en comparación a R. irregularis.

Summary: Zucchini is a vegetable of great agricultural and social relevance in Mexico, hence, the implementation of alternatives such as the use of products of biological origin, can contribute to the improvement and increase of profits in this crop. The objective of this study was to determine the effect of chemical and biological fertilization on the growth, yield, and profitability of the zucchini crop. The study was established under irrigation in Tlayacapan, Morelos, Mexico, where seedlings of Italian zucchini variety Adelita were transplanted. The treatments consisted of the application of seaweed extract [Ascophyllum nodosum (L.) Le Jolis] and Rhizophagus irregularis (Błaszk., Wubet, Renker & Buscot) C. Walker & A. Schüßler (2010) to the soil mixed with chemical fertilizers. A random complete block design with four repetitions was used. To evaluate crop growth and leaf area dry matter per plant was recorded, with which the growth rate of the crop, absolute growth rate, crop yield, weight, diameter, and length of the fruit were determined. In addition, an economic analysis was performed to determine the profitability of each treatment. Overall, it was observed that the application of 100% chemical fertilization promoted the largest leaf area, fresh plant weight, dry matter, absolute growth rate, crop growth rate, yield, and fruit weight in zucchini cultivation, which caused improved profitability. Fertilization with seaweed complemented chemical fertilization and generated a better response in the variables evaluated compared to R. irregularis.

https://doi.org/10.28940/terra.v40i0.1059 131 downloads

12.

Recomendaciones en el abordaje del hematoma intracerebral espontáneo durante la internación
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Pigretti, Santiago G.

; Mirofsky, Matías

; García, Darío E.

; Issac, Cristian

; Valdez, Pascual

; Persi, Gabriel G.

; Mamani, Carlos E.

; Guyon, Jorgelina

; Álvarez, Héctor

; Montes, Mariana

; Daza Aramayo, José M.

; Iturrieta, Pablo

; Chaves, Hernán

; Sarmiento, Verónica

; Tumino, Leandro

; Domeniconi, Gustavo

; Castagna, Rosa

; Sabio, Rodrigo

; Videtta, Walter

; Ciarrocchi, Nicolás

; Lerman, Damián

; Dossi, Daiana E.

; Balian, Natalia R.

; Velasquez, Mariela A.

; Rufino Saravia, Gonzalo

; Alet, Matías J.

; Rodríguez Lucci, Federico

; Ciardi, Celina

; Pujol Lereis, Virginia

; Claverie, Santiago

; Casanova, Matías

; González, Leonardo

; Mónaco, Juan Manuel

; Cárdenas, Rolando E.

; Cirio, Juan José

; Arturi, Jessica

; Requejo, Flavio

; Plou, Pedro L.

; Orzuza, Gabriela

; Bonardo, Pablo

; Díaz, María Fernanda

; Payaslian, Silvio

; Andrade, María Gabriela

; Gomez Schneider, Maia M.

; Romano, Marina

; Colla Machado, Pedro

; Arroyo, José

; Arcondo, María Florencia

; Svampa, Silvana

; Armenteros, Cristhian

; Tejada Jacob, Virginia

; Zurrú, María Cristina

Medicina (Buenos Aires)

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Nov 2022, Volume 82 Supl. 4 Páginas 1 - 56

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen El accidente cerebrovascular (ACV) constituye la principal causa de discapacidad de origen neuro- lógico en los adultos mayores a 40 años y la cuarta causa de muerte en Argentina. En los últimos diez años las publicaciones indexadas relacionadas al tratamiento del ACV isquémico fueron más numerosas que las de ACV hemorrágico. El objetivo de este material es proporcionar recomendaciones locales y actualiza- das del abordaje de pacientes con hematoma intraparenquimatoso espontáneo durante la internación. Para la redacción de este manuscrito se convocó a especialistas en esta enfermedad que conformaron grupos de trabajo. Se plantearon 10 tópicos centrales expresados como epidemiologia, atención inicial, imágenes, tratamiento de la presión arterial, reversión de antitrombóticos, indicación de cirugía, profilaxis anticonvulsivante, pronóstico, prevención de complicaciones y reinicio de antitrombóticos. De cada tópico se plantearon mediante preguntas PICO los interrogantes más frecuentes de la práctica diaria. Luego de una revisión sistemática de la literatura, se generaron recomendaciones evaluadas mediante sistema GRADE y consensuadas entre autores y pacientes.

Abstract Stroke is the leading cause of neurological disability in people over 40 years of age and the fourth leading cause of death in Argentina. In the last ten years, the indexed publications related to the treatment of ischemic stroke were more numerous than those of hemorrhagic stroke. The objective of this material is to provide local and updated recommendations for the management of patients with spontaneous intracere- bral hemorrhage during hospitalization. For the writing of this manuscript, diferent specialists were convened to form working groups. Ten central topics expressed as epidemiology, initial care, imaging, blood pressure treatment, reversal of antithrombotics, indication for surgery, seizure prophylaxis, prognosis, prevention of complications and resumption of antithrombotics were raised. For each topic, the most frequent questions of daily practice were raised through PICO questions. After a systematic review of the literature, recommendations were generated, evaluated using the GRADE system and agreed between authors and patients.

13.

Diagnosis and treatment of systemic mastocytosis in Brazil: Recommendations of a multidisciplinary expert panel
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Velloso, Elvira D. Rodrigues Pereira

; Padulla, Geórgia A.

; Cerqueira, Ana Maria Mósca de

; Sousa, Adriana Martins de

; Sandes, Alex Freire

; Traina, Fabiola

; Seguro, Fernanda Salles

; Nogueira, Frederico Lisboa

; Pereira, Grazielly de Fátima

; Boechat, José Laerte

; Pagnano, Katia Borgia Barbosa

; Marchi, Luan Lima

; Ensina, Luis Felipe

; Giavina-Bianchi, Mara

; Aun, Marcelo Vivolo

; Agondi, Rosana Câmara

; Santos, Fabio Pires de Souza

; Giavina-Bianchi, Pedro

Hematology, Transfusion and Cell Therapy

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Out 2022, Volume 44 Nº 4 Páginas 582 - 594

Resumo: En | Texto: En | PDF: En

ABSTRACT Introduction: Systemic Mastocytosis comprises a group of neoplastic diseases characterized by clonal expansion and infiltration of mast cells into several organs. The diagnosis and treatment of this disease may be challenging for non-specialists. Objective: Make suggestions or recommendations in Systemic Mastocytosis based in a panel of Brazilian specialists. Method and results: An online expert panel with 18 multidisciplinary specialists was convened to propose recommendations on the diagnosis and treatment of Systemic Mastocytosis in Brazil. Recommendations were based on discussions of topics and multiple-choice questions and were graded using the Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence Chart. Conclusion: Twenty-two recommendations or suggestions were proposed based on a literature review and graded according to the findings.

https://doi.org/10.1016/j.htct.2022.04.006

14.

ESTUDO ONE-POT DA APLICAÇÃO DO CATALISADOR DE GRUBBS DE PRIMEIRA GERAÇÃO EM REAÇÕES DE METÁTESE DA PIPERINA E EUGENOL: A INFLUÊNCIA DA LIGAÇÃO DUPLA TERMINAL
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Costa, Ana K. B.

; Fernandes, Kerlane A.

; Vieira, Vanessa B.

; França, Aline A. C.

; Lima, Wanessa A.

; Almeida, Pedro M. de

; Matos, José M. E. de

; Neto, Benedito S. L.

; Sá, José L. S.

; Martins, Francielle A.

Química Nova

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Ago 2022, Volume 45 Nº 8 Páginas 929 - 934

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

In this paper, the piperine (PIP) and eugenol (EUG) organic compounds were used as substrates in olefin metathesis reactions catalyzed by first-generation Grubbs catalyst (G1) - [RuCl2(PCy3)2(=CHPh)], Cy is cyclohexyl and Ph is phenyl, in a one-pot system. The reactions occurred at 50 ºC, for 24, 48, or 96 h using the two substrates simultaneously in the ratio Ru:PIP:EUG of 1:1:1 and 1:10:10 mol. The results were evaluated by GC-MS, discussed in terms of the electronic and steric characteristics of the G1, and the structural proprieties of the substrates. In the Ru:PIP:EUG ratio of 1:1:1 mol, a dimeric species was observed for the olefin metathesis of EUG, in all time studied and in an additional experiment at 70 ºC for 48 h. When the Ru:PIP:EUG ratio was 1:10:10 mol, this dimer was not observed. Isomerization processes also were observed at all temperatures and catalyst:substrates ratio. The reaction yield increased with the raise of substrates amount. There was no cross-metathesis reaction. This fact was attributed to the chelating effect of the double coordination of the PIP to the catalyst.

https://doi.org/10.21577/0100-4042.20170901

15.

Evolução e Estado Atual das Práticas de Implante Transcateter de Válvula Aórtica na América Latina – Estudo WRITTEN LATAM
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Bernardi, Fernando Luiz de Melo

; Ribeiro, Henrique Barbosa

; Nombela-Franco, Luis

; Cerrato, Enrico

; Maluenda, Gabriel

; Nazif, Tamim

; Lemos, Pedro Alves

; Sztejfman, Matias

; Lamelas, Pablo

; Echeverri, Dario

; Lopes, Marcelo Antonio Cartaxo Queiroga

; Brito Jr, Fábio Sândoli de

; Abizaid, Alexandre A.

; Mangione, José A.

; Eltchaninoff, Helene

; Søndergaard, Lars

; Rodes-Cabau, Josep

Arquivos Brasileiros de Cardiologia

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Jun 2022, Volume 118 Nº 6 Páginas 1085 - 1096

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: Implante transcateter de valva aórtica (TAVI) é um procedimento adotado em todo o mundo e suas práticas evoluem rapidamente. Variações regionais e temporais são esperadas. Objetivo: Comparar a prática de TAVI na América Latina com aquela no resto do mundo e avaliar suas mudanças na América Latina de 2015 a 2020. Método: A pesquisa foi realizada em centros de TAVI em todo o mundo entre março e setembro de 2015, e novamente nos centros latino-americanos entre julho de 2019 e janeiro de 2020. As seguintes questões foram abordadas: i) informação geral sobre os centros; ii) avaliação pré-TAVI; iii) técnicas do procedimento; iv) conduta pós-TAVI; v) seguimento. As respostas da pesquisa dos centros latino-americanos em 2015 (LATAM15) foram comparadas àquelas dos centros no resto do mundo (WORLD15) e ainda àquelas da pesquisa dos centros latino-americanos de 2020 (LATAM20). Adotou-se o nível de significância de 5% na análise estatística. Resultados: 250 centros participaram da pesquisa em 2015 (LATAM15=29; WORLD15=221) e 46 na avaliação LATAM20. No total, foram 73.707 procedimentos, sendo que os centros WORLD15 realizaram, em média, 6 e 3 vezes mais procedimentos do que os centros LATAM15 e LATAM20, respectivamente. Os centros latino-americanos realizaram menor número de TAVI minimalista do que os do restante do mundo, mas aumentaram significativamente os procedimentos menos invasivos após 5 anos. Quanto à assistência pós-procedimento, observaram-se menor tempo de telemetria e de manutenção do marca-passo temporário, além de menor uso de terapia dupla antiplaquetária nos centros LATAM20. Conclusão: A despeito do volume de procedimentos ainda significativamente menor, muitos aspectos da prática de TAVI nos centros latino-americanos evoluíram recentemente, acompanhando a tendência dos centros dos países desenvolvidos.

Abstract Background: Transcatheter aortic valve replacement (TAVR) is a worldwide adopted procedure with rapidly evolving practices. Regional and temporal variations are expected to be found. Objective: To compare TAVR practice in Latin America with that around the world and to assess its changes in Latin America from 2015 to 2020. Methods: A survey was applied to global TAVR centers between March and September 2015, and again to Latin-American centers between July 2019 and January 2020. The survey consisted of questions addressing: i) center’s general information; ii) pre-TAVR evaluation; iii) procedural techniques; iv) post-TAVR management; v) follow-up. Answers from the 2015 survey of Latin-American centers (LATAM15) were compared with those of other centers around the world (WORLD15) and with the 2020 updated Latin-American survey (LATAM20). A 5% level of significance was adopted for statistical analysis. Results: 250 centers participated in the 2015 survey (LATAM15=29; WORLD15=221) and 46 in the LATAM20. Combined centers experience accounted for 73 707 procedures, with WORLD15 centers performing, on average, 6- and 3-times more procedures than LATAM15 and LATAM20 centers, respectively. LATAM centers performed less minimalistic TAVR than WORLD15 centers, but there was a significant increase in less invasive procedures after 5 years in Latin-American centers. For postprocedural care, a lower period of telemetry and maintenance of temporary pacing wire, along with less utilization of dual antiplatelet therapy was observed in LATAM20 centers. Conclusion: Despite still having a much lower number of procedures, many aspects of TAVR practice in Latin-American centers have evolved in recent years, followingthe trend observed in developed country centers.

https://doi.org/10.36660/abc.20210327

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